Monday, June 9, 2008

Symptoms of Mesothelioma - Detection of this Cancer

In most cases, people usually ignore the symptoms of Mesothelioma due to their generic nature. This is because the early symptoms of mesothelioma can also be the indication of other common diseases. Furthermore, researches have concluded that a patient with prior exposure to asbestos may develop mesothelioma much later in his/her life, i.e. after 20 to 40 years of asbestos encounter. Thus, many patients disregard the possibility of developing mesothelioma due to something that happened much earlier in their lives.

Mesothelioma is a cancer in which the protective linings of the body’s internal organs get affected by malignant cells. These linings include:

•Pleura: the outer lining surrounding the lungs and chest cavity;
•Peritoneum: the lining of the abdominal cavity; and
•Pericardium: a sac holding the heart.

The symptoms of mesothelioma affecting these organs can vary due to the special nature and functions of the organs. Some of these symptoms are severe, and also some of the symptoms are rare. It is, therefore, recommended to contact a physician if the symptoms prevail.

Additionally, if mesothelioma is detected at early stages, the chances for a possible cure are high.

Following are the symptoms of mesothelioma, categorized by types:

Pleural Mesothelioma Symptoms:

•Shortness of breath
•Coughing up blood
•Pain in chest
•Pleural effusions (fluid accumulation in the lung lining)
•Back pain
•Hoarseness
•Weakness
•Problem in swallowing
•Loss of appetite
•Weight loss
•Excessive coughing
•Swelling
•Paralysis
•Fever

In severe cases, a pleural mesothelioma patient can develop pneumothorax or lung cancer (lung failure). Nonetheless, some patients may show almost no symptoms.

Peritoneal Mesothelioma Symptoms:

•Swelling or mass accumulation in the abdomen
•Weight Loss
•Abdominal pain
•Bowel obstruction
•Blood clots
•Fever
•Nausea
•Vomiting
•Hernia

Pericardium Mesothelioma Symptoms:

•Chest pain
•Shortness of breath
•Cough
•Unusual heart beating
•Irregular breathing patterns

These symptoms of mesothelioma can also be the indications of other minor diseases. However, if diagnosed soon, these symptoms can help the doctors to cure the cancer at a primitive stage. Remember that only a doctor can confirm the presence of mesothelioma by examining medical reports, asbestos exposure history, MRI and/or CT scan. In some cases, a needle biopsy can also be conducted.

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What is Mesothelioma?


Mesothelioma Patient

Throughout the past decade, the term "mesothelioma" has become more and more recognizable. Once an obscure disease that meant little to the general public, mention of this disease now conjures up thoughts and pictures of factories and mines strewn with asbestos and the unfortunate workers who were employed in those dangerous places.

Thanks to concerned medical professionals, researchers, and watchdog organizations, we're learning more and more about mesothelioma and how it affects the lives of those who are afflicted. However, there's still far to go as both better treatments and a cure for the disease are sought.

About the Disease

Simply put, mesothelioma is an aggressive form of cancer caused primarily by the inhalation of dangerous asbestos fibers. The disease attacks the mesothelium, a protective, two-layered membrane that covers the internal organs of the body including the lungs, heart and abdominal organs. Between these layers, the cells produce fluid, which allows easy movement of the heart and lungs within the chest cavity. The layer that covers the lungs is called the pleura, and the layer that covers the heart is called the pericardium. The peritoneum lines the abdominal cavity. Mesothelium also lines the male and female reproductive organs. Mesothelioma can affect any of these cells, but is usually seen in the pleural or peritoneal mesothelium. The most commonly diagnosed form of this cancer is pleural mesothelioma.

Mesothelioma takes anywhere from 20 to 50 years to develop, which is why older individuals are usually the victims. However, recent cases involving September 11th World Trade Center first responders and clean-up crews show that high concentrations of asbestos can cause the disease to develop much more rapidly. A few WTC workers have already died of the disease.

Effects of the Disease

The invasion of the mesothelium by cancer cells makes it very difficult for the patient to breathe, resulting in the need for oxygen, especially as the disease progresses. Those with the pleural form of mesothelioma may also suffer from pleural effusions. These effusions prevent the smooth movement of the lungs and other organs in the chest. Peritoneal mesothelioma also affects the stomach area and abdominal cavity, causing nausea, vomiting, or loss of appetite, which can result in dangerous weight loss. In addition to breathing difficulties and loss of appetite, mesothelioma victims also complain of excessive coughing, sleeping difficulties, persistent chest pain, fever, and pain in the lower back.

Mesothelioma, in general, is a very painful disease and because it is usually not diagnosed until it's in an advanced stage. For this reason, the symptoms are typically quite serious. Late diagnosis also means that the cancer is more likely to have metastasized, or spread, making successful mesothelioma treatment even more difficult.

Who Gets Mesothelioma?

Statistics show that, because of their work history, the disease most often affects men between the ages of 50 and 70 who were employed in an asbestos-laden environment before asbestos warnings and bans were in place in the 1970s. Though women still have a much lower frequency of the disease, cases of second-hand exposure to asbestos has prompted more diagnoses among women, especially those whose male family members worked with asbestos. The occupations most associated with mesothelioma are shipyard workers, electricians, plumbers, construction industry workers, pipefitters, boilermakers, and anyone subject to heavy exposure to dangerous asbestos and airborne asbestos fibers.

An abundance of cases have also demonstrated that mesothelioma can develop among people who lived in communities where asbestos factories or mines were located. In some instances, entire towns have been adversely affected by the presence of asbestos fibers in the air. For example, in Libby, Montana - site of a former vermiculite asbestos mine - hundreds have already died of mesothelioma.

Though still significantly rarer than other cancers, an estimated 2,000 to 3,000 new cases of mesothelioma are diagnosed each year in the United States. Other countries, notably the United Kingdom and Australia, report a much higher incidence of the disease. Nevertheless, the United States - like many other countries - has seen an increase in asbestos-caused cancer as men who worked in U.S. shipyards in the 1940s and 1950s, at the height of production, are now being diagnosed with mesothelioma.

Dealing with Mesothelioma

Mesothelioma is most often diagnosed in its late stages, and such a diagnosis is devastating to the individual and his/her family. Though research into the disease has been ongoing, there is currently no cure for mesothelioma. Some patients may be candidates for surgery to remove tumors or even an entire lung, but most are better treated with radiation or chemotherapy. More often than not, these treatments are palliative, serving to lessen the severity of the symptoms of the disease rather than offering a cure.

Medical professionals and research scientists, however, are constantly exploring new ways to combat the disease. For example, doctors know that some combinations of chemotherapy drugs work better than others and tests developed to ascertain earlier diagnosis of the disease or to monitor those most at risk have arrived on the scene.

Who's to Blame?

The reason someone develops mesothelioma is usually the lack of proper protection offered to those who worked with asbestos. Though the dangerous properties of asbestos and asbestos products have been evident for decades, many employers neglected to protect their workers from inhaling asbestos while on the job. It wasn't until public awareness of the dangers of the material were revealed in the 1970s that many employers began offering protective clothing such as respirators, gloves, aprons, and other such items to those working with asbestos on a daily basis.

Due to the negligence of employers, many companies who manufacture asbestos or products that contain asbestos have been subject to literally thousands of lawsuits filed by those who've been harmed by the material. Many of those lawsuits have come from individuals suffering from mesothelioma.

Treatments for Mesothelioma


Mesothelioma Treatment

A diagnosis of mesothelioma is always difficult, whether it is pleural mesothelioma or another variety. Because this is such an aggressive and stubborn form of cancer, patients and their families may have a difficult time addressing the issue of treatment, but because options for mesothelioma patients are steadily increasing, the discussion of treatment is quite important, even if all hope seems lost.

Each mesothelioma case is considered individually and there is no right or wrong treatment for the disease. What's best for you or your loved one will depend on a number of factors. Diagnostic tools such as x-rays, MRIs, CT scans, and biopsies will be used to determine these factors and these tests will assist the doctor and/or oncologist in determining the best treatment for the patient in question.

What are the Options?

Cancer treatment usually focuses upon destroying malignant cells and preserving healthy ones. This can be accomplished in a number of ways. At present, mesothelioma patients are faced with three major options for treatment of their disease - surgery, radiation, and chemotherapy. What course of treatment is recommended will largely depend on these issues:

  • The type of mesothelioma and location of the tumor
  • The size of the tumor(s)
  • The degree to which the cancer has spread or metastasized
  • The stage of the cancer - beginning, advanced, etc.
  • The age of the patient
  • The overall physical health of the patient

Setting up any type of treatment may involve seeing a variety of doctors, including an oncologist (cancer specialist), pulmonologist (lung specialist), or radiologist. Patience is sometimes necessary, but doctors will no doubt set up treatment as soon as possible after diagnosis.

Surgery

Surgery can be performed on mesothelioma patients for one of two reasons: in an attempt to cure the disease or for palliative reasons in order to keep the patient more comfortable and improve the quality of life. Unfortunately, because mesothelioma is almost always diagnosed in its late stages, curative surgery is not usually an option.

As tests are developed that may help to diagnose mesothelioma at an earlier stage, surgery may become more of an option in the future. At that point, doctors may be able to attempt to remove the cancer and some of the surrounding tissue in an attempt to stabilize the disease.

More often, however, surgery is used as a palliative measure. For example, doctors may opt for a surgery called a pleurodesis, which involves injecting talc into the lungs to prevent fluid from returning. A thoracentesis, a surgical procedure that removes fluid from the lungs by means of a thin needle, may also be recommended.

In severe cases, a pleurectomy may be recommended for palliative purposes. This involves removing the pleura - the lining of the lung - and can control fluid build-up and lessen pain and breathing difficulties.

Radiation Therapy

If a patients health is too fragile for surgery or chemotherapy, radiation is often recommended. Radiation causes the fewest side effects and is usually easier to tolerate than chemo. There are a few different forms of radiation therapy available to meso patients:

External beam radiation - the preferred type to treat mesothelioma, this type of radiation comes from a machine outside the body and is aimed toward affected areas. Usually administered 5-days-a-week for up to 5 weeks, this type of radiation is often used for palliative purposes - to lessen breathing difficulties, pain, bleeding, or difficulty swallowing - but seldom has much of an effect on the mesothelioma tumors. This type of radiation may also be used in addition to surgery.

Brachytherapy - Rarely prescribed for mesothelioma, this kind of radiation places radioactive material directly inside the lung or abdomen.

Chemotherapy

Like radiation, chemotherapy provides no cure for mesothelioma but can go a long way in providing relief from the horrendous symptoms of the disease. As researchers continue to test different combinations of chemotherapy drugs, patients continue to benefit from their findings, and someday, chemo may go a lot further in prolonging the life of a mesothelioma victim.

Chemotherapy is given in pill form or injected. In the case of mesothelioma patients, the drugs are given intrapleurally (into the chest cavity) or intraperitoneally (into the abdominal cavity). Doctors usually combine two drugs for the best result. Currently, the preferred combination is Alimta© (pemetrexed) and Cisplatin, but other drugs are used in tandem if deemed preferable for a specific patient. In some cases, patients can only tolerate a single drug so only one is used for treatment.

Other drugs are given to the patient to combat the unpleasant side effects of chemo, such as medication to relieve nausea and vomiting or vitamins to replace essential ones lost during chemotherapy.

Some patients decide that the side effects of chemotherapy are too severe and opt not to receive this treatment.

Clinical Trials

Clinical trials are the study of promising new treatments for a particular disease. These trials are constantly in need of patients who are willing to try these experimental treatments before they are approved by the FDA. Patients should speak to their doctors about current clinical trials available to them and if they might qualify to be a part of a particular study. Those opting to participate in a clinical trial should carefully weigh the pros and cons before agreeing to participate.

Alternative Therapies

Alternative therapies include potential treatment for a disease or its symptoms that are not part of the conventional treatment generally recommended for patients with the disease. These might include the use of vitamins or herbs or participation in therapies such as acupuncture, massage, or hypnosis.


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